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Applications of Biomaterials for Immunosuppression in Tissue Repair and Regeneration

  2021-07-30 11:46:00  
The immune system plays an essential role in tissue repair and regeneration. Regardless of innate or adaptive immune responses, immunosuppressive strategies such as macrophage polarization and regulatory T (Treg) cell induction can be used to modulate the immune system to promote tissue repair and regeneration. Biomaterials can improve the production of anti-inflflammatory macrophages and Treg cells by providing physiochemical cues or delivering therapeutics such as cytokines, small molecules, microRNA, growth factors, or stem cells in the damaged tissues. Herein, we present an overview of immunosuppressive modulation by biomaterials in tissue regeneration and highlight the mechanisms of macrophage polarization and Treg cell induction. Overall, we foresee that future biomaterials for regenerative strategies will entail more interactions between biomaterials and the immune cells, and more mechanisms of immunosuppression related to T cell subsets remain to be discovered and applied to develop novel biomaterials for tissue repair and regeneration.
 
This work was supported by the National Natural Science Foundation of China (31971260), Zhejiang Provincial Natural Science Funds for Distinguished Young Scholar (LR20C100001), Zhejiang Provincial Natural Science Foundation of China (LY19C100002), Key Laboratory of Orthopaedics of Zhejiang Province (grant no: ZJGK1804Y), Wenzhou Scientifific Research Project (Y20190136), and a seed grant from the Wenzhou Institute, University of Chinese Academy of Sciences (WIUCASQD2019004).

website link: https://doi.org/10.1016/j.actbio.2021.03.019