Red Blood Cell Membrane Based Nanomaterials for Immune Tolerance Modulation

2017-03-21 15:46:00
报告题目:Red Blood Cell Membrane Based Nanomaterials for Immune Tolerance Modulation and Cancer Radiotherapy
报告时间:今天(3月21日)上午10:40
报告地点:会议室2
报告人:Dr. Junjie Deng (邓俊杰),Department of Chemical Engineering, Northeastern University, USA
 
摘要:
The use of biomimic materials to manipulate the microenvironment in vivo to alter the immune system is a promising treatment for autoimmune disease, organ transplantation and cancer immunotherapy. Membrane of red blood cells (RBCs) comprises a myriad of sphingosine 1-phosphate (S1P), proteins, glycans, and acidic sialyl moieties that can actively suppress immune attack has been proposed as a promising candidate. This presentation focuses on the development of new injectable red blood cell membrane vesicle based scaffold with macroporous structure to modulate the in vivo immune tolerance microenvironment. This scaffold can in situ recruit dendritic cells (DCs) and affect the differentiation of DCs through the interaction of scaffold with DCs. In addition, synthesis of red blood cell membrane coated bismuth nanoparticles as radiosensitizer for enhanced X-ray radiotherapy will be discussed.
 
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