Stimuli-regulated Cancer Theranostics Based on Multifunctional Nanoparticles

2018-11-12 18:01:00
报告题目:Stimuli-regulated Cancer Theranostics Based on Multifunctional Nanoparticles
  侯仰龙,教育部长江学者特聘教授,国家杰出青年科学基金获得者,皇家化学会会士(FRSC),万人计划科技创新领军人才,国家重点研发计划纳米科技专项首席科学家,磁电功能材料与器件北京市重点实验室主任,北京大学教授、博士生导师。主要从事多功能磁性材料、新能源材料的控制合成及其在纳米生物医学与能源领域的应用探索研究。发展了单分散磁性纳米材料的通用制备方法,探索了磁性纳米颗粒在肿瘤等重大疾病的诊断与治疗的应用;设计制备了若干纳米结构杂化材料用于高性能的锂电池电极等。迄今发表学术论文140余篇,在国际和各类双边会议上作大会或分会邀请报告40余次。荣获北京市科技新星(2008)、教育部新世纪优秀人才(2009)、北京市优秀人才(2009)、霍英东优秀青年教师奖(2009)、青年科学之星新人奖(2010)、北京茅以升青年科技奖(2011)、绿叶生物医药杰出青年学者奖(2012)、中国化学会-英国皇家化学会青年化学奖(2013)、科技部中青年科技创新领军人才(2014)、中国电子学会优秀科技工作者(2015),全国优秀科技工作者(2016)、中国生物材料学会青年科学家奖(2018)和中国材料研究会科技奖一等奖(2018)。正主持国家重点研发计划,国家自然科学基金委重点项目、重大项目课题等。现任Rare Metals副主编,Advanced Science (Wiley)、Scientific Reports (NPG)、Science China Materials等期刊编委,中国材料研究会常务理事、中国材料研究会青年工作者委员会主任委员、中国化学会理事、中国生物材料学会理事、中国化学会青年化学工作者委员会副主任委员等。
Photothermal therapy (PTT), using light to cause thermal damage, is a revolutionary approach in tumor therapy because of its spatiotemporal controllability, high efficiency and minimal harm to normal tissues. However, without using imaging contrast agents, it is very difficult for PTT to achieve its precise therapeutic effects since its accuracy is compromised. In order to solve such problems, multimodal imaging-guided PTT has recently emerged and achieved rapid development in cancer diagnosis and treatment. With unique magnetic properties and feasible synthesis, magnetic nanoparticles (MNPs) have been widely used in imaging-guided cancer therapy. Among all of MNPs, iron carbides are emerging as promising theranostic agents for cancer treatment. The affiliation of carbon endows iron carbides with good absorption in near-infrared (NIR) and ultrasound signals for photothermal therapy (PTT) as well as photoacoustic tomography (PAT), respectively. Herein, we first introduce general protocol to produce monodisperse MNPs, and then highlight multifunctional Fe5C2 and Au-Fe2C MNPs with their synthetic process and theranostic applications. Owing that Fe5C2 and Au-Fe2C NPs possess magnetic features and additive photothermal characteristics, they are consequently developed as multifunctional probes for imaging-guided cancer therapy. What’s more, Au3Cu tetrapod nanocrystals (TPNCs) were prepared by a facile seed-mediated growth method for imaging-guided PTT for tumors in the NIR-II window. Because the special morphology of flake branches, they exhibited excellent NIR-II photothermal performance. Furthermore, Au3Cu TPNCs could achieve renal clearance through degradation in the tumor microenvironment after the process of PTT. In summary, we developed organic liquid phase to produce monodisperse multifucntional nanoparticles, including, Fe5C2, Au-Fe2C NPs and Au3Cu TPNCs were demonstrated capable of multimodal imaging-guided PTT for precise diagnosis and efficient cancer treatment.
Key words:Magnetic Nanoparticles;Photothermal Therapy; MRI
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