简介：马锐副教授本科毕业于吉林大学数学学院，博士毕业于清华大学高等研究院，并在德国马克斯普朗克复杂系统物理研究所访问两年。博士毕业后在美国耶鲁大学分子生物物理与生物化学学院从事博士后研究6年，于2020年回国，入选厦门大学“南强学者计划”，进入厦门大学物理科学与技术学院任副教授。研究兴趣主要为细胞膜力学与细胞骨架力学，分子马达的动力学与热力学。近些年来在Physical Reviewer Letter, Physical  Review E, PLOS Computational Biology 等期刊上发表论文十余篇，其中2018年发表在PLOS Computational Biology的文章被收录进Fprime1000数据库。

 

摘要：During clathrin-mediated endocytosis, a patch of flat plasma membrane is deformed inward towards the cytoplasm. In yeast cells, the invagination exhibits a tubular shape. While in mammalian cells, it is scaffolded into a spherical shape. In this talk, I will present our recent work on modelling the membrane morphology during endocytosis. We found that due to the large turgor pressure in yeast cells, a large amount of force is needed to pull a membrane tube. The magnitude of these forces strongly depends on how the base of the membrane is constrained. In mammalian cells, we found that the vesiculation pathway is similar to the constant area model but not the constant curvature model. Our results help resolve a long debating issue in the research of endocytosis.