Advanced In Vivo Fluorescence Imaging: Seeing is Believing

2017-11-23 16:40:00
报告题目:Advanced In Vivo Fluorescence Imaging: Seeing is Believing
报告时间:2017年11月27日 上午 9点
Fluorescent imaging in the second near-infrared window (NIR-II, 1.0~1.7 μm) is appealing in in vivo imaging due to minimal autofluorescence and negligible tissue scattering in this region, affording maximal penetration depth for deep tissue imaging with high feature fidelity. Herein, for the first time, we reported a new type of NIR-II QDs-Ag2S QDs and executed a series of in vivo imaging studies by using Ag2S QDs. The results show that, by using Ag2S QDs, the tissue penetration length can reach 1.5 cm, and the spatial and temporal resolution of the in vivo imaging can down to 25 µm and 50 ms, respectively, which are improved several to dozens of times in comparison with those using conventional fluorescence nanoprobes in the visible and the first near-infrared window (650-900 nm), facilitating in situ, real-time visualization of the biological events in vivo. With the advanced NIR-II fluorescence of Ag2S QDs, high signal to noise ratio imaging of tumor growth and angiogenesis, imaging-guided targeting drug-delivery and therapeutics, imaging-guided precision surgery of glioma, and stem cell tracking and regeneration in vivo, etc, have been achieved.
Figure. Characterization of Ag2S QDs and their in vivo real-time visualization of angiogenesis mediated by a subcutaneous xenograft 4T1 mammary tumor.

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