Biocompatible lanthanide materials for tumors targeting, imaging and inhibition

2018-08-06 17:17:00
报告题目:Biocompatible lanthanide materials for tumors targeting, imaging and inhibition
报告人:Dr. Ka-LeungWong
  黄嘉良教授(Dr. Ka-Leung Wong)于2002年获得香港城市大学学士学位。2002-2006年在黄永徳教授的指导下完成香港大学化学博士学位,之后获得英国皇家学会研究奖学金的支持,在英国杜伦大学化学院从事博士后研究,导师是皇家学会院士David Parker教授。黄嘉良教授自2009年起,在香港浸会大学任职, 目前黄嘉良教授担任香港浸会大学系主任。
  黄嘉良教授的研究工作主要包括镧系元素化学和光谱等方面的研究以及有关化学生物学应用。黄教授同时也是Journal of Luminescence的编辑,并担任ChemPlusChem杂志的国际顾问,黄教已在Nat. Biomed. Eng. 、Nat. Commun. 、Proc. Natl. Acad. Sci. USA、J. Am. Chem. Soc. 等国际学术期刊上发表论文超过120多篇。引用次数超过3000次,H-index 35。黄教授申请注册国际专利六项,其中有一专利技术“镧系元素工具箱”在2017年日内瓦国际发明展获得三项大奖。由于黄嘉良教授的突出贡献,2015年欧洲稀土元素及锕系元素协会(EuropeanRare Earth and Actinide Society (ERES))授予其青年科学家奖。
One of themajor limitations of the existing anticancer agents is their differentiation ofcancer cells and normal cells. Recently, some studies in the literature havesuggested thatsome overexpressed cancer cell cycle regulating proteins (e.g.Cyclin(s), Plk1 and EBNA1) can be the particular cancer targets. Several smallmolecules as their inhibitors have been reported; however, those reportedinhibitors are not emissive and cannot directly evaluate their effectiveness,such as real time imaging, biodistribution and pharmacokinetic studies. Over the recent two decades, luminescent lanthanide materials have shownextensive applications in the detection of various bioactive molecules and forin vitro/in vivo imaging, addressing the problem ofautofluorescence. For thisreason, one of our driving forces for synthesizing new lanthanide materials forimaging these cell cycle regulated protein relates to their uniquephotophysical properties, such as long emission lifetimes (effective eliminationof biological auto-fluorescence in time-resolved spectroscopy) andcharacteristic hypersensitive emissions, (providing real-time information aboutthe effect on coordination environment by surrounding entities, especially witheuropium) which are attractive substitutes to the more commonly used organicfluorophores.
In this seminar, I would like to share ourdevelopment recently on emissive lanthanide materials as dual bioprobes for invitro/in vivo imaging and inhibition of overexpressed tumor regulator proteins,such as Cyclin(s), Plk1 andEBNA1. It is hoped that the success in research could alsolead to the success in practice, thereby providing more powerful tools to getmore complete pictures of the roles of Cyclin(s)/Plk1/EBNA1.

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